SKU: WP10139 Categories: ,

SCG10 (phospho Ser73) Polyclonal Antibody

Price range: $288.00 through $368.00

SKU: WP10139-100
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Product details

Background:

This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010],

Specifications

TargetStathmin
ReactivityHuman, Mouse, Rat
ApplicationsIHC, IF, ELISA
MW(Calculated)21kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate
ModificationPhospho
Recommended Dilution RatioIHC 1:100-1:300;ELISA 1:5000;IF 1:50-200
CompositionLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification ProcessThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage Condition-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized phospho-peptide around the phosphorylation site of human SCG10 (phospho Ser73)
Sequence
SpecificityPhospho-SCG10 (S73) Polyclonal Antibody detects endogenous levels of SCG10 protein only when phosphorylated at S73.
Gene NameSTMN2
Protein NameStathmin-2
AliasSTMN2;SCG10;SCGN10;Stathmin-2;Superior cervical ganglion-10 protein;Protein SCG10
Organism-1Human
Gene ID-111075
SwissProt-1Q93045
Organism-2Mouse
Gene ID-220257
SwissProt-2P55821
Organism-3Rat
Gene ID-384510
SwissProt-3P21818
Organism-4
Gene ID-4
SwissProt-4
Cellular LocalizationCytoplasm . Cytoplasm, perinuclear region . Cell projection, growth cone. Membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, axon. Golgi apparatus. Endosome . Cell projection, lamellipodium. Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity). Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia. .
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