Name: SIRT1 (phospho Ser47) Polyclonal Antibody
SKU: WP9521
Price: 288 USD
Availability: InStock

SIRT1 (phospho Ser47) Polyclonal Antibody

Ucallm_WP9521-50

Price range: $288.00 through $368.00

Size

100μl

50μl

Clear

SKU: WP9521-100

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Product details

Background:

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008],

Specifications

Target	SIRT1
Reactivity	Human, Mouse
Applications	WB, ELISA, IHC
MW(Calculated)
MW(Observed)	85-110kD
Host Species	Rabbit
Isotype	IgG
Conjugate
Modification	Phospho
Recommended Dilution Ratio	WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
Composition	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification Process	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage Condition	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized phospho-peptide around the phosphorylation site of human SIRT1 (phospho Ser47)
Sequence
Specificity	Phospho-SIRT1 (S47) Polyclonal Antibody detects endogenous levels of SIRT1 protein only when phosphorylated at S47.
Gene Name	SIRT1
Protein Name	NAD-dependent protein deacetylase sirtuin-1
Alias	SIRT1;SIR2L1;NAD-dependent protein deacetylase sirtuin-1;hSIRT1;Regulatory protein SIR2 homolog 1;SIR2-like protein 1;hSIR2
Organism-1	Human
Gene ID-1	23411
SwissProt-1	Q96EB6
Organism-2	Mouse
Gene ID-2	93759
SwissProt-2	Q923E4
Organism-3
Gene ID-3
SwissProt-3
Organism-4
Gene ID-4
SwissProt-4
Cellular Localization	Nucleus, PML body . Cytoplasm . Nucleus . Recruited to the nuclear bodies via its interaction with PML (PubMed:12006491). Colocalized with APEX1 in the nucleus (PubMed:19934257). May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane (PubMed:15469825). Shuttles between nucleus and cytoplasm (By similarity). Colocalizes in the nucleus with XBP1 isoform 2 (PubMed:20955178). .; [SirtT1 75 kDa fragment]: Cytoplasm . Mitochondrion .