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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/SIRT6 mouse mAb
SKU: WM0604 Categories: ,

SIRT6 mouse mAb

Ucallm_WM0604-50

Price range: $268.00 through $328.00

SKU: WM0604-50
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Product details

Background:
This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016],

Specifications

TargetSIRT6
ReactivityHuman, Mouse, Rat, Monkey
ApplicationsWB, IF, IP
MW(Calculated)
MW(Observed)42kD
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioWB 1:500; IF/ICC1:100
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
PurificationThe antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Purity
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number5C11
ImmunogenPurified recombinant human SIRT6 protein expressed in E.coli.
Sequence
SpecificityThis antibody detects endogenous levels of SIRT6 and does not cross-react with related proteins.
Gene Namesirt6
Protein Name
Other Name2810449N18Rik; / AI043036; / Mono ADP ribosyltransferase sirtuin 6; / NAD-dependent protein deacetylase sirtuin-6; / Regulatory protein SIR2 homolog 6; / Regulatory protein SIR2 homolog; / SIR2 like 6; / SIR2 like protein 6; / Sir2 related protein type 6; / SIR2-like protein 6; / SIR2
SpeciesHuman
Gene ID-151548
UniprotQ8N6T7,
Species.1Mouse
Gene ID-2
Uniprot.1P59941
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
BackgroundThis gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016],
Cellular LocalizationNucleus . Chromosome . Chromosome, telomere . Endoplasmic reticulum . Predominantly nuclear (PubMed:18337721). Associated with pericentric heterochromatin and telomeric heterochromatin regions (PubMed:18337721, PubMed:27043296). Localizes to DNA damage sites: directly recognizes and binds double-strand breaks (DSBs) sites via a tunnel-like structure that has high affinity for DSBs (PubMed:21680843, PubMed:23911928, PubMed:27568560, PubMed:31995034, PubMed:32538779). A fraction localizes to the endoplasmic reticulum (PubMed:23552949). .
Tissue ExpressionBlood,Eye,Lung,Placenta,Spleen,Teratocarcinoma,
Signaling_pathwayHuman Diseases >> Cancer: overview >> Central carbon metabolism in cancer
Research Areas>>Nicotinate and nicotinamide metabolism; / >>Metabolic pathways; / >>Thermogenesis; / >>Central carbon metabolism in cancer
FunctionCatalytic activity:NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.,Catalytic activity:NADP(+) + protein-L-arginine = nicotinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine.,cofactor:Binds 1 zinc ion per subunit.,PTM:ADP-ribosylated (-auto).,similarity:Belongs to the sirtuin family.,similarity:Contains 1 deacetylase sirtuin-type domain.,subcellular location:Predominantly nuclear.,
RRID
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