Name: U-Blot® SIRT6 Rabbit mAb
SKU: WR4851
Price: 268 USD
Availability: InStock

U-Blot® SIRT6 Rabbit mAb

Ucallm_WR4851-50

Price range: $268.00 through $328.00

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50μl

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SKU: WR4851-50

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Product details

Background:This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016],

Specifications

Size	50μL/100μL
Target	SIRT6
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	39kD
MW(Observed)	39kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:500-1:2000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1014R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	sirt6
Protein Name
Other Name	2810449N18Rik; / AI043036; / Mono ADP ribosyltransferase sirtuin 6; / NAD-dependent protein deacetylase sirtuin-6; / Regulatory protein SIR2 homolog 6; / Regulatory protein SIR2 homolog; / SIR2 like 6; / SIR2 like protein 6; / Sir2 related protein type 6; / SIR2-like protein 6; / SIR2
Species	Human
Gene ID	51548
Uniprot	Q8N6T7,
Species.1	Mouse
Gene ID.1
Uniprot.1	P59941
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus . Chromosome . Chromosome, telomere . Endoplasmic reticulum . Predominantly nuclear (PubMed:18337721). Associated with pericentric heterochromatin and telomeric heterochromatin regions (PubMed:18337721, PubMed:27043296). Localizes to DNA damage sites: directly recognizes and binds double-strand breaks (DSBs) sites via a tunnel-like structure that has high affinity for DSBs (PubMed:21680843, PubMed:23911928, PubMed:27568560, PubMed:31995034, PubMed:32538779). A fraction localizes to the endoplasmic reticulum (PubMed:23552949). .
Tissue Expression	Blood,Eye,Lung,Placenta,Spleen,Teratocarcinoma,
Signaling_pathway	Human Diseases >> Cancer: overview >> Central carbon metabolism in cancer
Research Areas	>>Nicotinate and nicotinamide metabolism; / >>Metabolic pathways; / >>Thermogenesis; / >>Central carbon metabolism in cancer
Function	Catalytic activity:NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.,Catalytic activity:NADP(+) + protein-L-arginine = nicotinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine.,cofactor:Binds 1 zinc ion per subunit.,PTM:ADP-ribosylated (-auto).,similarity:Belongs to the sirtuin family.,similarity:Contains 1 deacetylase sirtuin-type domain.,subcellular location:Predominantly nuclear.,

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U-Blot® SIRT6 Rabbit mAb

Product details

Specifications

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U-Blot® SIRT6 Rabbit mAb

Product details

Specifications

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