Price range: $268.00 through $328.00
Background:
This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008],
| Target | SIVA |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 19kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein AA range: 1-50 |
| Sequence | |
| Specificity | SIVA Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | SIVA1 SIVA |
| Protein Name | Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP) |
| Other Name | |
| Species | Human |
| Gene ID-1 | 10572 |
| Uniprot | O15304, |
| Species.1 | Mouse |
| Gene ID-2 | |
| Uniprot.1 | O54926, |
| Species.2 | Rat |
| Gene ID-3 | |
| Uniprot.2 | P59692 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008], |
| Cellular Localization | Cytoplasm . Nucleus . In the nucleus, accumulates in dot-like structures. |
| Tissue Expression | Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon. |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> p53 signaling pathway |
| Research Areas | >>p53 signaling pathway |
| Function | cofactor:Isoform 1 binds 3 zinc ions. Isoform 2 binds 2 zinc ions.,Function:Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.,pharmaceutical:Could be used as a potentiator of cisplatin-based chemotherapy. Enhances cisplatin-mediated apoptosis, even under conditions where cisplatin resistance occurs due to elevated levels of BCL2 or BCL2L1.,PTM:Phosphorylated by ABL2/ARG in response to oxidative stress.,subcellular location:In the nucleus, accumulates in dot-like structures.,subunit:Binds through its N-terminal region to the C-terminus of CD27 and to PXMP2/PMP22. Binds to the C-terminus of TNFRSF18/GITR. Isoform 1 binds to BCL2L1/BCLX isoform Bcl-x(L) but not to BAX. Binds to capsid protein VP2 from coxsackievirus B3. Binding of SIVA1 to CD27 can be blocked by VP2.,tissue specificity:Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon., |
| RRID |
