SNAI 1 Polyclonal Antibody
Ucallm_WP14526-50
Price range: $268.00 through $328.00
Product details
Background:
snail family transcriptional repressor 1(SNAI1) Homo sapiens The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | SNAI1 |
| Reactivity | Human, Mouse, Monkey |
| Applications | WB, IP, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 29kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SNAI1. AA range:215-264 |
| Specificity | SNAI 1 Polyclonal Antibody detects endogenous levels of SNAI 1 protein. |
| Gene Name | SNAI1 |
| Protein Name | Zinc finger protein SNAI1(snail) |
| Other Name | SNAI1; / SNAH; / Zinc finger protein SNAI1; / Protein snail homolog 1; / Protein sna |
| Species | Human |
| Gene ID | 6615 |
| Uniprot | O95863, |
| Species.1 | Mouse |
| Gene ID.1 | 20613 |
| Uniprot.1 | Q02085 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs. . |
| Tissue Expression | Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines. |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Adherens junction |
| Research Areas | >>Adherens junction |
| Function | Function:Seems to be involved in embryonic mesoderm formation. Binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription.,similarity:Belongs to the snail C2H2-type zinc-finger protein family.,similarity:Contains 4 C2H2-type zinc fingers.,tissue specificity:Expressed in a variety of tissues with the highest expression in kidney., |
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