SNX13 rabbit pAb
Ucallm_WP3684-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | SNX13 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 105kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SNX13 AA range: 602-652 |
| Specificity | This antibody detects endogenous levels of SNX13 at Human/Mouse |
| Gene Name | SNX13 KIAA0713 |
| Protein Name | SNX13 |
| Other Name | Sorting nexin-13; / RGS domain- and PHOX domain-containing protein; / RGS-PX1 |
| Species | Human |
| Gene ID | 23161 |
| Uniprot | Q9Y5W8, |
| Species.1 | Mouse |
| Gene ID.1 | 217463 |
| Uniprot.1 | Q6PHS6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Early endosome membrane; Peripheral membrane protein; Cytoplasmic side . |
| Tissue Expression | Amygdala,Brain,Placenta,Testis, |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:May be involved in several stages of intracellular trafficking. Act as a GAP for Galphas.,similarity:Belongs to the sorting nexin family.,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 1 PXA domain.,similarity:Contains 1 RGS domain., |
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