SOCS5 Polyclonal Antibody
Ucallm_WP1794-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | SOCS5 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 58kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | SOCS5 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | SOCS5 CIS6 CISH5 CISH6 KIAA0671 |
| Protein Name | Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2 protein 6) (CIS-6) (Cytokine-inducible SH2-containing protein 5) |
| Other Name | |
| Species | Human |
| Gene ID | 9655 |
| Uniprot | O75159, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O54928 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | cytoplasm, |
| Tissue Expression | Brain,Placenta,Testis,Thalamus, |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Prolactin signaling pathway;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway |
| Research Areas | >>JAK-STAT signaling pathway; / >>Prolactin signaling pathway |
| Function | Domain:The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.,Function:SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS5 is involved in regulating T-helper cell differentiation by inhibition of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling (By similarity). May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SOCS box domain.,subunit:Interacts, via the first 50 AA, with IL4RA (through a box 1-containing cytpolasmic domain) and inhibits IL4 signaling., |
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