Somatostatin [ABT232] mouse mAb
Ucallm_WM1629-50
Price range: $268.00 through $328.00
Product details
Background:
The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | Somatostatin |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 12kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | IgG2b,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-400; IF 1:50-200; ELISA 1:500-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM232 |
| Immunogen | Synthesized peptide derived from human Somatostatin AA range: 50-116 |
| Specificity | The antibody can specifically recognize human Somatostatin protein. |
| Gene Name | SST |
| Protein Name | Growth hormone release inhibiting factor; Growth hormone release-inhibiting factor; Prepro somatostatin; SMS_HUMAN; SMST; Somatostatin 14; Somatostatin 28; Somatostatin-14; SST |
| Other Name | Growth hormone release inhibiting factor; / Growth hormone release-inhibiting factor; / Prepro somatostatin; / SMS_HUMAN; / SMST; / Somatostatin 14; / Somatostatin 28; / Somatostatin-14; / SST |
| Species | Human |
| Gene ID | 6750 |
| Uniprot | P61278, |
| Species.1 | Mouse |
| Gene ID.1 | 20604 |
| Uniprot.1 | P60041, |
| Species.2 | Rat |
| Gene ID.2 | 24797 |
| Uniprot.2 | P60042 |
| Cellular Localization | Cytoplasmic |
| Tissue Expression | Pancreas |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway |
| Research Areas | >>cAMP signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Growth hormone synthesis, secretion and action; / >>Gastric acid secretion |
| Function | Function:Somatostatin inhibits the release of somatotropin.,online information:Somatostatin entry,pharmaceutical:A synthetic analog known as octreotide or SMS 201-995 is available under the name Sandostatin (Novartis). It is used for the treatment of a variety of disorders including acromegaly and the symptomatic treatment of carcinoid tumors and vasoactive intestinal peptide tumors.,similarity:Belongs to the somatostatin family., |
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