Name: Sox2 mouse mAb
SKU: WM0567
Price: 268 USD
Availability: InStock

Product details

Background:
SRY-box 2(SOX2) Homo sapiens This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008],

Specifications

Target	SOX-2
Reactivity	Mouse
Applications	WB, FC, ICC
MW(Calculated)
MW(Observed)	35kD
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:1000; ICC 1:150
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	18F9
Immunogen	Purified recombinant mouse Sox2 protein fragments expressed in E.coli
Sequence
Specificity	This antibody detects endogenous levels of Sox2 and does not cross-react with related proteins.
Gene Name	sox2
Protein Name	Transcription factor SOX-2
Other Name	ANOP3; / cb236; / Delta EF2a; / lcc; / MCOPS3; / MGC148683; / MGC2413; / RGD1565646; / Sex determining region Y box 2; / SOX 2; / Sox2; / SOX2_HUMAN; / SRY; / sex determining region Y; / box 2; / SRY box containing gene 2; / SRY related HMG box 2; / SRY related HMG box gene 2; / SRY-box 2; / Transcription factor SOX 2; / Transcription factor SOX-2; / ysb.
Species	Human
Gene ID-1	6657
Uniprot	P48431,
Species.1	Mouse
Gene ID-2	20674
Uniprot.1	P48432
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	SRY-box 2(SOX2) Homo sapiens This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008],
Cellular Localization	Nucleus speckle . Cytoplasm . Nucleus . Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity). .
Tissue Expression	Fetal brain,Lung,Retina,
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway
Research Areas	>>Hippo signaling pathway; / >>Signaling pathways regulating pluripotency of stem cells
Function	Disease:Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.,Function:Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.,online information:Sox2 entry,PTM:Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.,similarity:Contains 1 HMG box DNA-binding domain.,
RRID