Highly expressed in liver and kidney. Also found in skeletal muscle, fetal liver, brain, testis, skin and the gastrointestinal tract. Within brain, expression is higher in the cerebral cortex with lower levels in the medulla and spinal cord.
Signaling_pathway
Research Areas
>>Arginine and proline metabolism; / >>Metabolic pathways
Function
Catalytic activity:Agmatine + H(2)O = putrescine + urea.,cofactor:Manganese .,pathway:Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine (ADC route): step 1/1.,similarity:Belongs to the arginase family. Agmatinase subfamily.,tissue specificity:Highly expressed in liver and kidney. Also found in skeletal muscle, fetal liver, brain, testis, skin and the gastrointestinal tract.,