SPP2A rabbit pAb
Ucallm_WP17333-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq, Feb 2012],
Specifications
| Size | 50μL/100μL |
| Target | SPP2A |
| Reactivity | Human, Mouse |
| Applications | WB, IHC |
| MW(Calculated) | 57kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SPP2A AA range: 66-116 |
| Specificity | This antibody detects endogenous levels of SPP2A at Human/Mouse |
| Gene Name | SPPL2A IMP3 PSL2 PSEC0147 |
| Protein Name | SPP2A |
| Other Name | |
| Species | Human |
| Gene ID | 84888 |
| Uniprot | Q8TCT8, |
| Species.1 | Mouse |
| Gene ID.1 | 66552 |
| Uniprot.1 | Q9JJF9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Late endosome membrane; Multi-pass membrane protein . Lysosome membrane; Multi-pass membrane protein . Membrane; Multi-pass membrane protein; Lumenal side . Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane. |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Functions as an intramembrane protease. Functions in ITM2B processing.,similarity:Belongs to the peptidase A22B family.,similarity:Contains 1 PA (protease associated) domain.,subunit:Interacts with ITM2B., |
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