SPY2 Polyclonal Antibody
Ucallm_WP3361-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul
Specifications
| Size | 50μL/100μL |
| Target | SPY2 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 34kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | SPY2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | SPRY2 |
| Protein Name | Protein sprouty homolog 2 (Spry-2) |
| Other Name | |
| Species | Human |
| Gene ID | 10253 |
| Uniprot | O43597, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9QXV8 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytoskeleton . Cell projection, ruffle membrane . Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor). . |
| Tissue Expression | Brain,Muscle,Skin, |
| Signaling_pathway | Human Diseases >> Cancer: overview >> MicroRNAs in cancer |
| Research Areas | >>MicroRNAs in cancer |
| Function | Domain:The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.,Function:May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.,induction:By FGF signaling.,similarity:Belongs to the sprouty family.,similarity:Contains 1 SPR (sprouty) domain.,subcellular location:Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor)., |
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