SR-1B Polyclonal Antibody
Ucallm_WP14564-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015],
Specifications
| Size | 50μL/100μL |
| Target | SR-1B |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 43kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human 5-HT-1B. AA range:201-250 |
| Specificity | SR-1B Polyclonal Antibody detects endogenous levels of SR-1B protein. |
| Gene Name | HTR1B |
| Protein Name | 5-hydroxytryptamine receptor 1B |
| Other Name | HTR1B; / HTR1DB; / 5-hydroxytryptamine receptor 1B; / 5-HT-1B; / 5-HT1B; / S12; / Serotonin 1D beta receptor; / 5-HT-1D-beta; / Serotonin receptor 1B |
| Species | Human |
| Gene ID | 3351 |
| Uniprot | P28222, |
| Species.1 | Mouse |
| Gene ID.1 | 15551 |
| Uniprot.1 | P28334, |
| Species.2 | Rat |
| Gene ID.2 | 25075 |
| Uniprot.2 | P28564 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> cAMP signaling pathway |
| Research Areas | >>cAMP signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Serotonergic synapse; / >>Taste transduction |
| Function | Function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.,PTM:Palmitoylated.,PTM:Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation.,similarity:Belongs to the G-protein coupled receptor 1 family., |
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