Name: SR-4 Polyclonal Antibody
SKU: WP14572
Price: 268 USD
Availability: InStock

SR-4 Polyclonal Antibody

Ucallm_WP14572-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP14572-100

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Product details

Background:

This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010],

Specifications

Size	50μL/100μL
Target	SR-4
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	43kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human 5-HT-4. AA range:21-70
Specificity	SR-4 Polyclonal Antibody detects endogenous levels of SR-4 protein.
Gene Name	HTR4
Protein Name	5-hydroxytryptamine receptor 4
Other Name	HTR4; / 5-hydroxytryptamine receptor 4; / 5-HT-4; / 5-HT4; / Serotonin receptor 4
Species	Human
Gene ID	3360
Uniprot	Q13639,
Species.1	Mouse
Gene ID.1	15562
Uniprot.1	P97288,
Species.2	Rat
Gene ID.2	25324
Uniprot.2	Q62758
Cellular Localization	Cell membrane; Multi-pass membrane protein. Endosome. Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli. .
Tissue Expression	Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle.
Signaling_pathway	Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
Research Areas	>>Calcium signaling pathway; / >>cAMP signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Serotonergic synapse
Function	Alternative products:Additional isoforms seem to exist,Function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.,subunit:Isoform 5-HT4(A) interacts with MAGI2, MPP3, SLC9A3R1 and SNX27 isoforms 1 and 2. Isoform 5-HT4(E) interacts with INADL, NOS1 and SEC23A. Isoform 5-HT4(A) forms a complex including SLC9A3R1 and EZR.,tissue specificity:Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle.,