Price range: $268.00 through $328.00
Background:
The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | SR-7 |
| Reactivity | Human, Mouse, Rat |
| Applications | IF, ELISA |
| MW(Calculated) | 54kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications; |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HTR7. AA range:391-440 |
| Specificity | SR-7 Polyclonal Antibody detects endogenous levels of SR-7 protein. |
| Gene Name | HTR7 |
| Protein Name | 5-hydroxytryptamine receptor 7 |
| Other Name | HTR7; / 5-hydroxytryptamine receptor 7; / 5-HT-7; / 5-HT7; / 5-HT-X; / Serotonin receptor 7 |
| Species | Human |
| Gene ID | 3363 |
| Uniprot | P34969, |
| Species.1 | Mouse |
| Gene ID.1 | 15566 |
| Uniprot.1 | P32304, |
| Species.2 | Rat |
| Gene ID.2 | 65032 |
| Uniprot.2 | P32305 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in terms of expression. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway |
| Research Areas | >>Ras signaling pathway; / >>Calcium signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Serotonergic synapse |
| Function | Alternative products:Isoform A and isoform B appear to be expressed at higher levels,Function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels, and isoform D is a minor isoform., |
