Product details
Background:
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- Please choose product options by visiting SR-2A Polyclonal Antibody.
- Please choose product options by visiting SR-2C Polyclonal Antibody.
- Please choose product options by visiting SR-3D Polyclonal Antibody.
SR-BI rabbit pAb
Ucallm_WP6239-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | SCARB1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 61kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SR-BI |
| Specificity | This antibody detects endogenous levels of SR-BI at Human, Mouse,Rat |
| Gene Name | SCARB1 CD36L1 CLA1 |
| Protein Name | Scavenger receptor class B member 1 (SRB1) (CD36 and LIMPII analogous 1) (CLA-1) (CD36 antigen-like 1) (Collagen type I receptor, thrombospondin receptor-like 1) (SR-BI) (CD antigen CD36) |
| Other Name | |
| Species | Human |
| Gene ID | 949 |
| Uniprot | Q8WTV0, |
| Species.1 | Mouse |
| Gene ID.1 | 20778 |
| Uniprot.1 | Q61009, |
| Species.2 | Rat |
| Gene ID.2 | 25073 |
| Uniprot.2 | P97943 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae. |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Endocrine system >> Aldosterone synthesis and secretion |
| Research Areas | |
| Function | Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells . Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux . Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity .; (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry . Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate .; (Microbial infection) Mediates uptake of M.fortuitum, E.coli and S.aureus.; (Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding. |
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