SRGP1 rabbit pAb
Ucallm_WP16982-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016],
Specifications
| Size | 50μL/100μL |
| Target | SRGP1 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 119kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SRGP1 AA range: 159-209 |
| Specificity | This antibody detects endogenous levels of SRGP1 at Human/Mouse |
| Gene Name | SRGAP1 ARHGAP13 KIAA1304 |
| Protein Name | SRGP1 |
| Other Name | |
| Species | Human |
| Gene ID | 57522 |
| Uniprot | Q7Z6B7, |
| Species.1 | Mouse |
| Gene ID.1 | 117600 |
| Uniprot.1 | Q91Z69 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | cytoplasm,cytosol, |
| Tissue Expression | Expressed in brain, lung, kidney, and testis. |
| Signaling_pathway | |
| Research Areas | >>Axon guidance |
| Function | Function:GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.,sequence Caution:Intron retention.,similarity:Contains 1 FCH domain.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with ROBO1, CDC42 and RHOA.,tissue specificity:Expressed in brain, lung, kidney, and testis., |
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