Stat6 Monoclonal Antibody
Ucallm_WM0430-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
Specifications
| Size | 50μL/100μL |
| Target | Stat6 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Applications | WB, IF, ELISA |
| MW(Calculated) | 94kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 6F8 |
| Immunogen | Purified recombinant fragment of human Stat6 expressed in E. Coli. |
| Specificity | Stat6 Monoclonal Antibody detects endogenous levels of Stat6 protein. |
| Gene Name | STAT6 |
| Protein Name | Signal transducer and activator of transcription 6 |
| Other Name | STAT6; / Signal transducer and activator of transcription 6; / IL-4 Stat |
| Species | Human |
| Gene ID | 6778 |
| Uniprot | P42226, |
| Species.1 | Mouse |
| Gene ID.1 | 20852 |
| Uniprot.1 | P52633 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation. |
| Tissue Expression | Uterus, |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Necroptosis;Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Organismal Systems >> Immune system >> Th17 cell differentiation;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Immune disease >> Inflammatory bowel disease;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway |
| Research Areas | >>Necroptosis; / >>JAK-STAT signaling pathway; / >>Th1 and Th2 cell differentiation; / >>Th17 cell differentiation; / >>Hepatitis B; / >>Pathways in cancer; / >>Inflammatory bowel disease |
| Function | Function:Carries out a dual Function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.,PTM:Tyrosine phosphorylated following stimulation by IL-4 and IL-3.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus in response to phosphorylation.,subunit:Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif., |
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