STIP1/HOP Rabbit pAb
Ucallm_WP5948-50
Price range: $268.00 through $328.00
Product details
Background:
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009],
Specifications
| Size | 50μL/100μL |
| Target | STIP1/HOP |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB |
| MW(Calculated) | |
| MW(Observed) | 64kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC1:50-200; WB 1:1000-2000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human STIP1/HOP AA range: 250-300 |
| Specificity | This antibody detects endogenous levels of STIP1/HOP at Human, Mouse,Rat |
| Gene Name | STIP1 |
| Protein Name | STIP1/HOP |
| Other Name | Stress-induced-phosphoprotein 1; / STI1; / Hsc70/Hsp90-organizing protein; / Hop; / Renal carcinoma antigen NY-REN-11; / Transformation-sensitive protein IEF SSP 3521 |
| Species | Human |
| Gene ID | 10963 |
| Uniprot | P31948, |
| Species.1 | Mouse |
| Gene ID.1 | 20867 |
| Uniprot.1 | Q60864, |
| Species.2 | Rat |
| Gene ID.2 | 192277 |
| Uniprot.2 | O35814 |
| Cellular Localization | Cytoplasm . Nucleus . Dynein axonemal particle . |
| Tissue Expression | B-cell lymphoma,Brain,Cajal-Retzius cell,Epithelium,Fetal brain cortex,Kera |
| Signaling_pathway | Human Diseases >> Neurodegenerative disease >> Prion disease |
| Research Areas | >>Prion disease |
| Function | Domain:The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90.,Function:Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB).,similarity:Contains 2 STI1 domains.,similarity:Contains 9 TPR repeats.,subunit:Forms a complex with HSC70 and HSPCA/HSP-86 and HSPCB/HSP-84. Interacts with PACRG., |
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