SKU: WP17239 Categories: ,

STON2 rabbit pAb

Price range: $268.00 through $328.00

SKU: WP17239-100
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Product details

Background:

This gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific proteins are internalized. The encoded protein has also been shown to participate in synaptic vesicle recycling through interaction with synaptotagmin 1 required for neurotransmission. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],

Specifications

TargetSTON2
ReactivityHuman, Mouse
ApplicationsWB, IF, FC, ELISA, IHC
MW(Calculated)100kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioWB 1:500-2000; IF/ICC1:50-200; ELISA 1:2000-20000; IHC 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human STON2 AA range: 47-97
Sequence
SpecificityThis antibody detects endogenous levels of STON2 at Human/Mouse
Gene NameSTON2 STN2 STNB
Protein NameSTON2
Other Name
SpeciesHuman
Gene ID-185439
UniprotQ8WXE9,
Species.1Mouse
Gene ID-2108800
Uniprot.1Q8BZ60
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
BackgroundThis gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific proteins are internalized. The encoded protein has also been shown to participate in synaptic vesicle recycling through interaction with synaptotagmin 1 required for neurotransmission. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
Cellular LocalizationCytoplasm . Membrane . Cell junction, synapse, synaptosome . Some fraction is membrane-associated.
Tissue ExpressionUbiquitous.
Signaling_pathway
Research Areas
FunctionDomain:The Asn-Pro-Phe (NPF) motifs, which are found in proteins involved in the endocytic pathway, mediate the interaction with the EH domain of SYT1, SYT2, EPS15, EPS15R and ITSN1.,Function:Adapter protein involved in endocytic machinery. May be involved in the vesicle recycling. May facilitate clathrin-coated vesicle uncoating.,similarity:Belongs to the Stoned B family.,similarity:Contains 1 MHD (mu homology) domain.,similarity:Contains 1 SHD (stonin homology) domain.,subcellular location:Some fraction is membrane-associated.,subunit:Interacts with the second C2 domain of synaptotagmins SYT1 and SYT2. Interacts with EPS15, EPS15R and ITSN1. Interacts indirectly with the AP-2 adapter complex.,tissue specificity:Ubiquitous.,
RRID
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