SUOX rabbit pAb
Ucallm_WP4373-50
Price range: $268.00 through $328.00
Product details
Background:
Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | SUOX |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 60kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SUOX AA range: 64-114 |
| Specificity | This antibody detects endogenous levels of SUOX at Human/Mouse/Rat |
| Gene Name | SUOX |
| Protein Name | SUOX |
| Other Name | |
| Species | Human |
| Gene ID | 6821 |
| Uniprot | P51687, |
| Species.1 | Mouse |
| Gene ID.1 | 211389 |
| Uniprot.1 | Q8R086, |
| Species.2 | Rat |
| Gene ID.2 | 81805 |
| Uniprot.2 | Q07116 |
| Cellular Localization | Mitochondrion intermembrane space . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | >>Sulfur metabolism; / >>Metabolic pathways |
| Function | Catalytic activity:Sulfite + O(2) + H(2)O = sulfate + H(2)O(2).,cofactor:Binds 1 protoheme group.,cofactor:Molybdenum (molybdopterin).,Disease:Defects in SUOX are the cause of isolated sulfite oxidase deficiency (ISOD) [MIM:272300]; also known as sulfocysteinuria. ISOD is characterized by neurological abnormalities including multicystic leukoencephalopathy with brain atrophy. Patients often suffer from seizures. Often leads to death at an early age.,pathway:Energy metabolism; sulfur metabolism.,similarity:Contains 1 cytochrome b5 heme-binding domain.,subunit:Homodimer., |
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