SURF-1 Polyclonal Antibody
Ucallm_WP14625-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | SURF-1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 30kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SURF1. AA range:171-220 |
| Specificity | SURF-1 Polyclonal Antibody detects endogenous levels of SURF-1 protein. |
| Gene Name | SURF1 |
| Protein Name | Surfeit locus protein 1 |
| Other Name | SURF1; / SURF-1; / Surfeit locus protein 1 |
| Species | Human |
| Gene ID | 6834 |
| Uniprot | Q15526, |
| Species.1 | Mouse |
| Gene ID.1 | 20930 |
| Uniprot.1 | P09925, |
| Species.2 | Rat |
| Gene ID.2 | 64463 |
| Uniprot.2 | Q9QXU2 |
| Cellular Localization | Mitochondrion inner membrane; Multi-pass membrane protein . |
| Tissue Expression | Colon,Kidney,Skin,Stomach, |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Defects in SURF1 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions that is commonly associated with systemic cytochrome c oxidase (COX) deficiency.,Function:Probably involved in the biogenesis of the COX complex.,similarity:Belongs to the SURF1 family., |
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