SWS rabbit pAb
Ucallm_WP17768-50
Price range: $268.00 through $328.00
Product details
Background:
This gene belongs to the G-protein coupled receptor 1 family, opsin subfamily. It encodes the blue cone pigment gene which is one of three types of cone photoreceptors responsible for normal color vision. Defects in this gene are the cause of tritan color blindness (tritanopia). Affected individuals lack blue and yellow sensory mechanisms while retaining those for red and green. Defective blue vision is characteristic. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | SWS |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA, IHC |
| MW(Calculated) | |
| MW(Observed) | 38kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SWS |
| Specificity | This antibody detects endogenous levels of Human SWS |
| Gene Name | OPN1SW BCP |
| Protein Name | Short-wave-sensitive opsin 1 (Blue cone photoreceptor pigment) (Blue-sensitive opsin) (BOP) |
| Other Name | Short-wave-sensitive opsin 1; / Blue cone photoreceptor pigment; / Blue-sensitive opsin; / BOP |
| Species | Human |
| Gene ID | 611 |
| Uniprot | P03999, |
| Species.1 | Mouse |
| Gene ID.1 | 12057 |
| Uniprot.1 | P51491, |
| Species.2 | Rat |
| Gene ID.2 | 81644 |
| Uniprot.2 | Q63652 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Photoreceptor inner segment . Cell projection, cilium, photoreceptor outer segment . Cytoplasm, perinuclear region . |
| Tissue Expression | The three color pigments are found in the cone photoreceptor cells (PubMed:2937147). Expressed throughout the epidermis and dermis, primarily in the stratum granulosum in the facial and abdominal skin (at protein level) (PubMed:30168605). Expressed in dermal fibroblasts (at protein level) (PubMed:31380578). Expressed in melanocytes (at protein level) (PubMed:31730232). |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Defects in OPN1SW are the cause of tritan color blindness (tritanopia) [MIM:190900].,Function:Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.,online information:Retina International's Scientific Newsletter,PTM:Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.,similarity:Belongs to the G-protein coupled receptor 1 family.,similarity:Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.,tissue specificity:The three color pigments are found in the cone photoreceptor cells., |
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