Product details
Background:
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SYG rabbit pAb
Ucallm_WP17896-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | GARS |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB |
| MW(Calculated) | 81kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human N-ternal SYG |
| Specificity | This antibody detects endogenous levels of SYG at Human, Mouse,Rat |
| Gene Name | GARS |
| Protein Name | Glycine--tRNA ligase (Diadenosine tetraphosphate synthetase) (AP-4-A synthetase) (Glycyl-tRNA synthetase) (GlyRS) |
| Other Name | Glycine--tRNA ligase; / Diadenosine tetraphosphate synthetase; / AP-4-A synthetase; / Glycyl-tRNA synthetase; / GlyRS |
| Species | Human |
| Gene ID | 2617 |
| Uniprot | P41250, |
| Species.1 | Mouse |
| Gene ID.1 | 353172 |
| Uniprot.1 | Q9CZD3, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q5I0G4 |
| Cellular Localization | Cytoplasm . Cell projection, axon . Secreted . Secreted, extracellular exosome . In transfected COS7 cells, not detected in mitochondria, nor in Golgi apparatus (PubMed:17035524). Secreted by motor neuron, possibly through the exosome pathway (By similarity). .; [Isoform 1]: Mitochondrion . Cytoplasm .; [Isoform 2]: Cytoplasm . Cell projection, axon . |
| Tissue Expression | Widely expressed, including in brain and spinal cord.; [Isoform 2]: Expressed in brain, spinal cord, muscle, heart and spleen.; [Isoform 1]: Expressed in brain, spinal cord, muscle, heart, spleen and liver. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) . Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis . |
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