Price range: $268.00 through $328.00
Background:
This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
| Size | 50μL/100μL |
| Target | Synuclein-β |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 14kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Synuclein beta. AA range:85-134 |
| Specificity | Synuclein-β Polyclonal Antibody detects endogenous levels of Synuclein-β protein. |
| Gene Name | SNCB |
| Protein Name | Beta-synuclein |
| Other Name | SNCB; / Beta-synuclein |
| Species | Human |
| Gene ID | 6620 |
| Uniprot | Q16143, |
| Species.1 | Mouse |
| Gene ID.1 | 104069 |
| Uniprot.1 | Q91ZZ3, |
| Species.2 | Rat |
| Gene ID.2 | 113893 |
| Uniprot.2 | Q63754 |
| Cellular Localization | Cytoplasm. |
| Tissue Expression | Expressed predominantly in brain; concentrated in presynaptic nerve terminals. |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCB is found in spheroids but not in inclusions.,Function:Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a TP53/p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.,PTM:Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.,similarity:Belongs to the synuclein family.,tissue specificity:Expressed predominantly in brain; concentrated in presynaptic nerve terminals., |
