SKU: WP14660 Categories: ,

T2R7 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP14660-100
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Product details

Background:

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetT2R7
ReactivityHuman, Mouse, Rat
ApplicationsWB, IF, ELISA
MW(Calculated)
MW(Observed)36kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human TAS2R7. AA range:47-96
SpecificityT2R7 Polyclonal Antibody detects endogenous levels of T2R7 protein.
Gene NameTAS2R7
Protein NameTaste receptor type 2 member 7
Other NameTAS2R7; / Taste receptor type 2 member 7; / T2R7; / Taste receptor family B member 4; / TRB4
SpeciesHuman
Gene ID50837
UniprotQ9NYW3,
Species.1Mouse
Gene ID.1
Uniprot.1P59530
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembrane; Multi-pass membrane protein.
Tissue ExpressionExpressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
Signaling_pathway
Research Areas>>Taste transduction
FunctionFunction:Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.,miscellaneous:Several bitter taste receptors are expressed in a single taste receptor cell.,similarity:Belongs to the G-protein coupled receptor T2R family.,tissue specificity:Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.,
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