TAF II p135/p105 Polyclonal Antibody
Ucallm_WP14672-50
Price range: $268.00 through $328.00
Product details
Background:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and
Specifications
| Size | 50μL/100μL |
| Target | TAF II p135/p105 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 110kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TAF4. AA range:941-990 |
| Specificity | TAF II p135/p105 Polyclonal Antibody detects endogenous levels of TAF II p135/p105 protein. |
| Gene Name | TAF4/TAF4B |
| Protein Name | Transcription initiation factor TFIID subunit 4/Transcription initiation factor TFIID subunit 4B |
| Other Name | TAF4; / TAF2C; / TAF2C1; / TAF4A; / TAFII130; / TAFII135; / Transcription initiation factor TFIID subunit 4; / RNA polymerase II TBP-associated factor subunit C; / TBP-associated factor 4; / Transcription initiation factor TFIID 130 kDa subunit; / TAF; / II; / 130 |
| Species | Human |
| Gene ID | 6874;6875 |
| Uniprot | O00268;Q92750 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus. |
| Tissue Expression | |
| Signaling_pathway | Human Diseases >> Neurodegenerative disease >> Huntington disease |
| Research Areas | >>Basal transcription factors; / >>Huntington disease |
| Function | Function:Makes part of TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone.,similarity:Belongs to the TAF4 family.,similarity:Contains 1 TAFH (NHR1) domain.,subunit:TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP. Interacts with SV40 Large T antigen., |
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