TAF II p68 Polyclonal Antibody
Ucallm_WP14675-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012],
Specifications
| Size | 50μL/100μL |
| Target | TAF II p68 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 62kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TAF15. AA range:351-400 |
| Specificity | TAF II p68 Polyclonal Antibody detects endogenous levels of TAF II p68 protein. |
| Gene Name | TAF15 |
| Protein Name | TATA-binding protein-associated factor 2N |
| Other Name | TAF15; / RBP56; / TAF2N; / TATA-binding protein-associated factor 2N; / 68 kDa TATA-binding protein-associated factor; / TAF; / II; / 68; / TAFII68; / RNA-binding protein 56 |
| Species | Human |
| Gene ID | 8148 |
| Uniprot | Q92804 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . Shuttles from the nucleus to the cytoplasm. |
| Tissue Expression | Ubiquitous. Observed in all fetal and adult tissues. |
| Signaling_pathway | Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer |
| Research Areas | >>Basal transcription factors; / >>Transcriptional misregulation in cancer |
| Function | Disease:A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9; 17)(q22; q11) with NR4A3.,Function:RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).,PTM:Arg-206 is dimethylated, probably to asymmetric dimethylarginine.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the RRM TET family.,similarity:Contains 1 RanBP2-type zinc finger.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Belongs to the RNA polymerase II (Pol II) transcriptional multiprotein complex, together with the TATA-binding protein (TBP) and other TBP-associated factors (TAF(II)s). Binds SF1.,tissue specificity:Ubiquitous. Observed in all fetal and adult tissues., |
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