TAF1B Polyclonal Antibody
Ucallm_WP2047-50
Price range: $268.00 through $328.00
Product details
Background:
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016],
Specifications
| Size | 50μL/100μL |
| Target | TAF1B |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 64kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TAF1B Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | TAF1B |
| Protein Name | TATA box-binding protein-associated factor RNA polymerase I subunit B (RNA polymerase I-specific TBP-associated factor 63 kDa) (TAFI63) (TATA box-binding protein-associated factor 1B) (TBP-associated factor 1B) (Transcription initiation factor SL1/TIF-IB subunit B) |
| Other Name | |
| Species | Human |
| Gene ID | 9014 |
| Uniprot | Q53T94, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P97358, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | D3ZYB7 |
| Cellular Localization | Nucleus, nucleolus. |
| Tissue Expression | Colon,Corpus callosum, |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Component of the transcription factor SL1/TIFIB complex involved in the assembly of the PIC (preinitiation complex).,similarity:Belongs to the TAF1 family.,subunit:Component of the transcription factor SL1/TIFIB complex which is composed of TBP and at least TAF1A, TAF1B and TAF1C. In the complex, interacts directly with TBP, TAF1A and TAF1C. Interaction of the SL1/TIFIB subunits with TBP excludes interaction with the transcription factor IID (TFIID) subunits. This mutually exclusive binding directs the formation of promoter and RNA polymerase-selective TBP-TAF complexes., |
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