SKU: WP16521 Categories: ,

TBCD rabbit pAb

Price range: $268.00 through $328.00

SKU: WP16521-100
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Product details

Background:

Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetTBCD
ReactivityHuman, Mouse
ApplicationsWB
MW(Calculated)131kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human TBCD AA range: 419-469
SpecificityThis antibody detects endogenous levels of TBCD at Human/Mouse
Gene NameTBCD KIAA0988 SSD1 TFCD PP1096
Protein NameTBCD
Other Name
SpeciesHuman
Gene ID6904
UniprotQ9BTW9,
Species.1Mouse
Gene ID.1108903
Uniprot.1Q8BYA0
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell junction, tight junction . Lateral cell membrane . Cytoplasm . Cell junction, adherens junction . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localized in cell-cell contacts. .
Tissue ExpressionUbiquitously expressed.
Signaling_pathway
Research Areas
FunctionFunction:Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB).,induction:Down-regulated by shear stress.,similarity:Belongs to the TBCD family.,similarity:Contains 3 HEAT repeats.,subunit:Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.,tissue specificity:Ubiquitously expressed.,
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