TBCD rabbit pAb
Ucallm_WP16521-50
Price range: $268.00 through $328.00
Product details
Background:
Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | TBCD |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 131kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TBCD AA range: 419-469 |
| Specificity | This antibody detects endogenous levels of TBCD at Human/Mouse |
| Gene Name | TBCD KIAA0988 SSD1 TFCD PP1096 |
| Protein Name | TBCD |
| Other Name | |
| Species | Human |
| Gene ID | 6904 |
| Uniprot | Q9BTW9, |
| Species.1 | Mouse |
| Gene ID.1 | 108903 |
| Uniprot.1 | Q8BYA0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell junction, tight junction . Lateral cell membrane . Cytoplasm . Cell junction, adherens junction . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localized in cell-cell contacts. . |
| Tissue Expression | Ubiquitously expressed. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB).,induction:Down-regulated by shear stress.,similarity:Belongs to the TBCD family.,similarity:Contains 3 HEAT repeats.,subunit:Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.,tissue specificity:Ubiquitously expressed., |
Please login to post questions
Related products
