TBL1 mouse mAb
Ucallm_WM0556-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have bee
Specifications
| Size | 50μL/100μL |
| Target | TBL1X |
| Reactivity | Human |
| Applications | WB, ICC |
| MW(Calculated) | |
| MW(Observed) | 58kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000; ICC 1:100 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 7E8 |
| Immunogen | Purified recombinant human TBL1 protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of TBL1X and does not cross-react with related proteins. |
| Gene Name | TBL1X |
| Protein Name | |
| Other Name | EBI; / F box like/WD repeat protein TBL1X; / F-box-like/WD repeat-containing protein TBL1X; / SMAP 55; / SMAP55; / TBL 1; / TBL 1X; / TBL1; / TBL1X; / TBL1X_HUMAN; / Transducin; / beta; / like 1; / Transducin; / beta; / like 1 X linked; / Transducin; / beta; / like 1X linked; / Transducin beta like 1 X linked; / Transducin beta like 1X; / Transducin beta like 1X protein; / Transducin beta like protein 1, X linked; / Transducin beta-like protein 1X; / Transducin-beta-like protein 1; / X-linked. |
| Species | Human |
| Gene ID | 6907 |
| Uniprot | O60907, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9QXE7 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Colocalized with MECP2 to the heterochromatin foci. . |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Wnt signaling pathway |
| Research Areas | >>Wnt signaling pathway |
| Function | Disease:Defects in TBL1X may be involved in the pathogenesis of ocular albinism with late-onset sensorineural deafness (OASD). OASD is an X-linked disorder characterized by ocular albinism and progressive sensineural hearing loss in the fourth and fifth decades of life. OASD may be caused by deletion of both GPR143/OA1 and TBL1X adjacent genes; TBL1X defects possibly causing the hearing phenotype.,Domain:The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.,Function:F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.,similarity:Belongs to the WD repeat EBI family.,similarity:Contains 1 F-box-like domain.,similarity:Contains 1 LisH domain.,similarity:Contains 8 WD repeats.,subunit:Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Probably part of other corepressor complexes, that do not contain NCOR1 and NCOR2. Interacts with histones H2B, H3a and H4.,tissue specificity:Ubiquitous., |
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