Price range: $268.00 through $328.00
Background:
This gene encodes a member of the beta-transducin protein family. Most proteins of the beta-transducin family are involved in regulatory functions. This protein is possibly involved in some intracellular signaling pathway. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | TBL2 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 50kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TBL2. AA range:381-430 |
| Specificity | TBL2 Polyclonal Antibody detects endogenous levels of TBL2 protein. |
| Gene Name | TBL2 |
| Protein Name | Transducin beta-like protein 2 |
| Other Name | TBL2; / WBSCR13; / Transducin beta-like protein 2; / WS beta-transducin repeats protein; / WS-betaTRP; / Williams-Beuren syndrome chromosomal region 13 protein |
| Species | Human |
| Gene ID | 26608 |
| Uniprot | Q9Y4P3, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9R099 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | endoplasmic reticulum,integral component of endoplasmic reticulum membrane, |
| Tissue Expression | Kidney,Testis,Whole embryo, |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Haploinsufficiency of TBL2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM:194050]. WBS is a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 7 WD repeats., |
