SKU: WM1268 Categories: ,

TBR1 [PTR1395] mouse mAb

Price range: $268.00 through $328.00

SKU: WM1268-50
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Product details

Background:
This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq, Dec 2015],

Specifications

Size50μL/100μL
TargetTBR1
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)74kD
MW(Observed)74kD
Host SpeciesMouse
IsotypeIgM,kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:100-400; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationThe antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRMMR1395
ImmunogenAA range: 1-682
SpecificityThis antibody detects endogenous levels of TBR1 protein.
Gene NameTBR1
Protein NameT-box brain protein 1 (T-brain-1) (TBR-1) (TES-56)
Other Name
SpeciesHuman
Gene ID10716
UniprotQ16650,
Species.1Mouse
Gene ID.1
Uniprot.1Q64336
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus
Tissue ExpressionBrain.
Signaling_pathway
Research Areas
FunctionFunction:Probable transcriptional regulator involved in developmental processes. TBR1 is required for normal brain development.,similarity:Contains 1 T-box DNA-binding domain.,tissue specificity:Brain.,
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