TBX5 Monoclonal Antibody
Ucallm_WM0438-50
Price range: $268.00 through $328.00
Product details
Background:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | TBX5 |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | 58kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 13A2 |
| Immunogen | Purified recombinant fragment of TBX5 expressed in E. Coli. |
| Specificity | TBX5 Monoclonal Antibody detects endogenous levels of TBX5 protein. |
| Gene Name | TBX5 |
| Protein Name | T-box transcription factor TBX5 |
| Other Name | TBX5; / T-box transcription factor TBX5; / T-box protein 5 |
| Species | Human |
| Gene ID | 6910 |
| Uniprot | Q99593, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P70326 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . Shuttles between the cytoplasm and the nucleus. Acetylation at Lys-339 promotes nuclear retention. . |
| Tissue Expression | Lung,Spleen, |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Defects in TBX5 are the cause of Holt-Oram syndrome (HOS) [MIM:142900]. HOS is a developmental disorder affecting the heart and upper limbs. It is characterized by thumb anomaly and atrial septal defects.,Function:Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation.,similarity:Contains 1 T-box DNA-binding domain., |
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