SKU: WP14736 Categories: ,

TESK2 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP14736-100
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Product details

Background:

testis-specific kinase 2(TESK2) Homo sapiens This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],

Specifications

Size50μL/100μL
TargetTESK2
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)65kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human TESK2. AA range:201-250
SpecificityTESK2 Polyclonal Antibody detects endogenous levels of TESK2 protein.
Gene NameTESK2
Protein NameDual specificity testis-specific protein kinase 2
Other NameTESK2; / Dual specificity testis-specific protein kinase 2; / Testicular protein kinase 2
SpeciesHuman
Gene ID10420
UniprotQ96S53,
Species.1Mouse
Gene ID.1230661
Uniprot.1Q8VCT9,
Species.2Rat
Gene ID.2170908
Uniprot.2Q924U5
Cellular LocalizationNucleus .
Tissue ExpressionPredominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells.
Signaling_pathway
Research Areas
FunctionAlternative products:Experimental confirmation may be lacking for some isoforms,Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,cofactor:Manganese.,enzyme regulation:Activated by autophosphorylation on Ser-219.,Function:Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,tissue specificity:Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells.,
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