Price range: $268.00 through $328.00
Background:
This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],
| Size | 50μL/100μL |
| Target | TFPI-2 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 13kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human TFPI2. AA range:186-235 |
| Specificity | TFPI-2 Polyclonal Antibody detects endogenous levels of TFPI-2 protein. |
| Gene Name | TFPI2 |
| Protein Name | Tissue factor pathway inhibitor 2 |
| Other Name | TFPI2; / Tissue factor pathway inhibitor 2; / TFPI-2; / Placental protein 5; / PP5 |
| Species | Human |
| Gene ID | 7980 |
| Uniprot | P48307, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O35536 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. |
| Tissue Expression | Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:This inhibitor contains three inhibitory domains.,Function:May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.,similarity:Contains 2 BPTI/Kunitz inhibitor domains.,similarity:Contains 3 BPTI/Kunitz inhibitor domains.,tissue specificity:Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy., |
