TGR5 Polyclonal Antibody
Ucallm_WP14760-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | TGR5 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA, IHC |
| MW(Calculated) | 35kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GPBAR. AA range:11-60 |
| Specificity | TGR5 Polyclonal Antibody detects endogenous levels of TGR5 protein. |
| Gene Name | GPBAR1 |
| Protein Name | G-protein coupled bile acid receptor 1 |
| Other Name | GPBAR1; / TGR5; / G-protein coupled bile acid receptor 1; / G-protein coupled receptor GPCR19; / hGPCR19; / Membrane-type receptor for bile acids; / M-BAR; / hBG37; / BG37 |
| Species | Human |
| Gene ID | 151306 |
| Uniprot | Q8TDU6, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q80SS6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum., |
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