Price range: $268.00 through $328.00
Background:
Tyrosine 3-monooxygenase encoded by TH is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have be associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
| Size | 50μL/100μL |
| Target | Tyrosine Hydroxylase |
| Reactivity | Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 58kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC:1:50-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Tyrosine Hydroxylase. AA range:5-54 |
| Specificity | TH Polyclonal Antibody detects endogenous levels of TH protein. |
| Gene Name | TH |
| Protein Name | Tyrosine 3-monooxygenase |
| Other Name | TH; / TYH; / Tyrosine 3-monooxygenase; / Tyrosine 3-hydroxylase; / TH |
| Species | Human |
| Gene ID | 7054 |
| Uniprot | P07101, |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | Rat |
| Gene ID.2 | 25085 |
| Uniprot.2 | P04177 |
| Cellular Localization | |
| Tissue Expression | |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Prolactin signaling pathway;Organismal Systems >> Nervous system >> Dopaminergic synapse;Human Diseases >> Neurodegenerative disease >> Parkinson disease |
| Research Areas | |
| Function |
