Price range: $499.00 through $699.00
Background:
The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
| Specification | 50μL;100μL |
| Target | Thioredoxin |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | 12kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate | |
| Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications. |
| Composition | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification Process | Affinity purification |
| Puity | |
| Storage Condition | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | |
| Immunogen | Purified recombinant fusion protein with Thioredoxin tag. |
| Sequence | |
| Specificity | Thioredoxin Monoclonal Antibody detects endogenous levels of Thioredoxin protein. |
| Gene Name | TXN |
| Protein Name | Thioredoxin |
| Alias | TXN;TRDX;TRX;TRX1;Thioredoxin;Trx;ATL-derived factor;ADF;Surface-associated sulphydryl protein;SASP |
| Organism-1 | Human |
| Gene ID-1 | 7295 |
| SwissProt-1 | P10599 |
| Organism-2 | Mouse |
| Gene ID-2 | |
| SwissProt-2 | P10639 |
| Organism-3 | |
| Gene ID-3 | |
| SwissProt-3 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Cellular Localization | Nucleus . Cytoplasm . Secreted . Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA) (PubMed:9108029). Predominantly in the cytoplasm in non irradiated cells (PubMed:11118054). Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054). Secreted by a leaderless secretory pathway (PubMed:1332947). . |
