SKU: WP2828 Categories: ,

THNS2 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP2828-100
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Product details

Background:

This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011],

Specifications

Size50μL/100μL
TargetTHNS2
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)53kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 91-140
SpecificityTHNS2 Polyclonal Antibody detects endogenous levels of protein.
Gene NameTHNSL2
Protein NameThreonine synthase-like 2 (TSH2) (Secreted osteoclastogenic factor of activated T-cells) (SOFAT)
Other Name
SpeciesHuman
Gene ID55258
UniprotQ86YJ6,
Species.1Mouse
Gene ID.1
Uniprot.1Q80W22,
Species.2Rat
Gene ID.2
Uniprot.2Q5M7T9
Cellular Localization[Isoform SOFAT]: Secreted. Secreted by activated T-cells via a calcineurin-independent pathway.
Tissue ExpressionBrain,Colon,Ovarian carcinoma,Skin,Tongue,
Signaling_pathway
Research Areas
Functioncofactor:Pyridoxal phosphate.,Function:Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate.,similarity:Belongs to the serine/threonine dehydratase family.,
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