Name: TIM-1 Polyclonal Antibody
SKU: WP15829
Price: 268 USD
Availability: InStock

TIM-1 Polyclonal Antibody

Ucallm_WP15829-50

Price range: $268.00 through $328.00

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50μl

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SKU: WP15829-100

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Product details

Background:

The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4, 12 and 19. [provided by RefSeq, Apr 2015],

Specifications

Size	50μL/100μL
Target	TIM-1
Reactivity	Human
Applications	IHC
MW(Calculated)
MW(Observed)	40-50kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthetic peptide from human protein at AA range: 40-100
Specificity	The antibody detects endogenous TIM-1
Gene Name	HAVCR1 KIM1 TIM1 TIMD1
Protein Name	Hepatitis A virus cellular receptor 1 (HAVcr-1) (Kidney injury molecule 1) (KIM-1) (T-cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T-cell membrane protein 1) (TIM-1) (TIM)
Other Name	Hepatitis A virus cellular receptor 1; / HAVcr-1; / Kidney injury molecule 1; / KIM-1; / T-cell immunoglobulin and mucin domain-containing protein 1; / TIMD-1; / T-cell membrane protein 1; / TIM-1; / TIM
Species	Human
Gene ID	26762
Uniprot	Q96D42,
Species.1	Mouse
Gene ID.1	171283
Uniprot.1	Q5QNS5
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Single-pass type I membrane protein .
Tissue Expression	Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.
Signaling_pathway
Research Areas
Function	Function:May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus.,polymorphism:HHAV seropositivity protects against atopy in individuals with the variants Met-Thr-Thr-Val-Pro-157 ins and Met-Thr-Thr-Thr-Val-Pro-157 ins. Modernisation has led to a reduction in HAV seroprevalence and thus, may be, to an increase of expression of atopy, such as asthma, allergic rhinitis and atopic dermatitis. Allelic variation does not affect HAV-infection rates in Caucasians, Asians and African Americans.,similarity:Belongs to the immunoglobulin superfamily. TIM family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,tissue specificity:Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.,

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TIM-1 Polyclonal Antibody

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TIM-1 Polyclonal Antibody

Product details

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