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TIM8B rabbit pAb
Ucallm_WP16902-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009],
Specifications
| Size | 50μL/100μL |
| Target | TIM8B |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF |
| MW(Calculated) | 9kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-200; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TIM8B AA range: 1-51 |
| Specificity | This antibody detects endogenous levels of TIM8B at Human/Mouse/Rat |
| Gene Name | TIMM8B DDP2 DDPL TIM8B |
| Protein Name | TIM8B |
| Other Name | |
| Species | Human |
| Gene ID | 26521 |
| Uniprot | Q9Y5J9, |
| Species.1 | Mouse |
| Gene ID.1 | 30057 |
| Uniprot.1 | P62077, |
| Species.2 | Rat |
| Gene ID.2 | 64372 |
| Uniprot.2 | P62078 |
| Cellular Localization | Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side . |
| Tissue Expression | Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM8B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.,Function:Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.,similarity:Belongs to the small Tim family.,subunit:Heterohexamer; possibly composed of 3 copies of TIMM8B and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22.,tissue specificity:Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle., |
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