Product details
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TIMM8A rabbit pAb
Ucallm_WP6757-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TIMM8A |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 11kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TIMM8A |
| Specificity | This antibody detects endogenous levels of TIMM8A at Human, Mouse,Rat |
| Gene Name | TIMM8A DDP DDP1 TIM8A |
| Protein Name | Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1) (X-linked deafness dystonia protein) |
| Other Name | |
| Species | Human |
| Gene ID | 1678 |
| Uniprot | O60220, |
| Species.1 | Mouse |
| Gene ID.1 | 30058 |
| Uniprot.1 | Q9WVA2, |
| Species.2 | Rat |
| Gene ID.2 | 84383 |
| Uniprot.2 | Q9WVA1 |
| Cellular Localization | Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side . |
| Tissue Expression | Highly expressed in fetal and adult brain, followed by fetal lung, liver and kidney. Also expressed in heart, placenta, lung, liver, kidney, pancreas, skeletal muscle and heart. |
| Signaling_pathway | |
| Research Areas | |
| Function | Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development. |
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