Name: TLE4 Polyclonal Antibody
SKU: WP14794
Price: 268 USD
Availability: InStock

TLE4 Polyclonal Antibody

Ucallm_WP14794-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP14794-100

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Product details

Background:

caution:Product of a dubious CDS prediction. Found in the 3’UTR of TLE4. No homolog. Large scale identification of a phosphorylated peptide (PubMed:15302935) would require further confirmation., function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES., similarity:Belongs to the WD repeat Groucho/TLE family., similarity:Contains 7 WD repeats., subunit:Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2., tissue specificity:In all tissues examined, mostly in brain, and muscle.,

Specifications

Size	50μL/100μL
Target	TLE4
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	83kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human TLE4. AA range:161-210
Specificity	TLE4 Polyclonal Antibody detects endogenous levels of TLE4 protein.
Gene Name	TLE4
Protein Name	Transducin-like enhancer protein 4
Other Name	TLE4; / KIAA1261; / Transducin-like enhancer protein 4
Species	Human
Gene ID	7091
Uniprot	Q04727,
Species.1	Mouse
Gene ID.1	21888
Uniprot.1	Q62441,
Species.2	Rat
Gene ID.2	25565
Uniprot.2	Q07141
Cellular Localization	Nucleus.
Tissue Expression	In all tissues examined, mostly in brain, and muscle.
Signaling_pathway	Environmental Information Processing >> Signal transduction >> Wnt signaling pathway;Environmental Information Processing >> Signal transduction >> Notch signaling pathway
Research Areas	>>Wnt signaling pathway; / >>Notch signaling pathway
Function	Caution:Product of a dubious CDS prediction. Found in the 3'UTR of TLE4. No homolog. Large scale identification of a phosphorylated peptide (PubMed:15302935) would require further confirmation.,Function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.,similarity:Belongs to the WD repeat Groucho/TLE family.,similarity:Contains 7 WD repeats.,subunit:Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2.,tissue specificity:In all tissues examined, mostly in brain, and muscle.,