TLR8 Polyclonal Antibody
Ucallm_WP5798-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | TLR8 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-500; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Recombinant Protein of TLR8 |
| Specificity | The antibody detects endogenous TLR8 protein. |
| Gene Name | TLR8 |
| Protein Name | Toll-like receptor 8 |
| Other Name | Toll-like receptor 8; / CD288 |
| Species | Human |
| Gene ID | 51311 |
| Uniprot | Q9NR97, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P58682 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endosome membrane; Single-pass type I membrane protein . Endosomal localization confers distinctive proteolytic processing. . |
| Tissue Expression | Expressed in myeloid dendritic cells, monocytes, and monocyte-derived dendritic cells. |
| Signaling_pathway | Organismal Systems >> Immune system >> Neutrophil extracellular trap formation;Organismal Systems >> Immune system >> Toll-like receptor signaling pathway |
| Research Areas | >>Neutrophil extracellular trap formation; / >>Toll-like receptor signaling pathway; / >>Coronavirus disease - COVID-19 |
| Function | Function:Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.,similarity:Belongs to the Toll-like receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 24 LRR (leucine-rich) repeats.,subunit:Binds MYD88 via their respective TIR domains.,tissue specificity:Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells., |
Please login to post questions
Related products
