Product details
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TMEM119 rabbit pAb
Ucallm_WP6169-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TMEM119 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 31kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TMEM119 |
| Specificity | This antibody detects endogenous levels of TMEM119 at Human, Mouse |
| Gene Name | TMEM119 PSEC0199 UNQ731/PRO1415 |
| Protein Name | Transmembrane protein 119 |
| Other Name | |
| Species | Human |
| Gene ID | 338773 |
| Uniprot | Q4V9L6, |
| Species.1 | Mouse |
| Gene ID.1 | 231633 |
| Uniprot.1 | Q8R138 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . Cytoplasm . Endoplasmic reticulum membrane . |
| Tissue Expression | Expressed in brain microglia (at protein level). Elevated expression levels seen in the brain of patients with Alzheimer disease. Expressed by osteoblast-like cells in bone tissues and follicular dendritic cells in lymphoid tissues. |
| Signaling_pathway | |
| Research Areas | |
| Function | Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts . May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity). |
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