Name: TNF-β Polyclonal Antibody
SKU: WP14814
Price: 268 USD
Availability: InStock

Product details

Background:

The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012],

Specifications

Size	50μL/100μL
Target	TNFB
Reactivity	Human, Mouse, Rat, Monkey
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	22kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human TNF-beta. AA range:17-66
Specificity	TNF-β Polyclonal Antibody detects endogenous levels of TNF-β protein.
Gene Name	LTA
Protein Name	Lymphotoxin-alpha
Other Name	LTA; / TNFB; / TNFSF1; / Lymphotoxin-alpha; / LT-alpha; / TNF-beta; / Tumor necrosis factor ligand superfamily member 1
Species	Human
Gene ID	4049
Uniprot	P01374,
Species.1	Mouse
Gene ID.1	16992
Uniprot.1	P09225,
Species.2	Rat
Gene ID.2	25008
Uniprot.2	Q06332
Cellular Localization	Secreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated.
Tissue Expression	Lymph,Peripheral blood leukocyte,Peripheral blood mononuclear cells,Peripheral blood mononu
Signaling_pathway	Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway;Environmental Information Processing >> Signal transduction >> TNF signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
Research Areas	>>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>NF-kappa B signaling pathway; / >>TNF signaling pathway; / >>Type I diabetes mellitus; / >>Human T-cell leukemia virus 1 infection; / >>Herpes simplex virus 1 infection
Function	Disease:Genetic variations in LTA are associated with susceptibility to leprosy type 4 (LPRS4) [MIM:610988]; also known as susceptibility to age-dependent leprosy. Leprosy is a chronic infectious disease of peripheral sensory nerves caused by Mycobacterium leprae.,Disease:Genetic variations in LTA are associated with susceptibility to psoriatic arthritis [MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. Psoriatic arthritis has been defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative arthritis) associated with psoriasis.,Function:Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.,online information:Lymphotoxin entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the tumor necrosis factor family.,subcellular location:The homotrimer is secreted. The heterotrimer is membrane-associated.,subunit:Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.,

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TNF-β Polyclonal Antibody

Product details

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TNF-β Polyclonal Antibody

Product details

Specifications

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