TNF-R2 Polyclonal Antibody
Ucallm_WP14811-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | TNF-R2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 48kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TNF Receptor II. AA range:376-425 |
| Specificity | TNF-R2 Polyclonal Antibody detects endogenous levels of TNF-R2 protein. |
| Gene Name | TNFRSF1B |
| Protein Name | Tumor necrosis factor receptor superfamily member 1B |
| Other Name | TNFRSF1B; / TNFBR; / TNFR2; / Tumor necrosis factor receptor superfamily member 1B; / Tumor necrosis factor receptor 2; / TNF-R2; / Tumor necrosis factor receptor type II; / TNF-RII; / TNFR-II; / p75; / p80 TNF-alpha receptor; / CD antigen CD120b; / Etanercept |
| Species | Human |
| Gene ID | 7133 |
| Uniprot | P20333, |
| Species.1 | Mouse |
| Gene ID.1 | 21938 |
| Uniprot.1 | P25119, |
| Species.2 | Rat |
| Gene ID.2 | 156767 |
| Uniprot.2 | Q80WY6 |
| Cellular Localization | [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Tumor necrosis factor-binding protein 2]: Secreted. |
| Tissue Expression | Muscle,PNS,Urine, |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Adipocytokine signaling pathway;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> TNF signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>TNF signaling pathway; / >>Adipocytokine signaling pathway; / >>Amyotrophic lateral sclerosis; / >>Pathways of neurodegeneration - multiple diseases; / >>Human immunodeficiency virus 1 infection |
| Function | Function:Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.,online information:Clinical information on Enbrel,pharmaceutical:Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe rheumatoid arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an immunoglobulin Fc chain. It binds to TNF-alpha and blocks its interactions with receptors.,PTM:A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.,PTM:Phosphorylated; mainly on serine residues and with a very low level on threonine residues.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Binds to TRAF2., |
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